CAS No.:
Methanol, 1-bromo-,1-acetate
Molecular Structure:
590-97-6 Molecular Structure
Molecular Weight:
1.614 g/cm 3
Boiling Point:
132.7 ˇăC at 760 mmHg
Flash Point:
59 ˇăC
Superlist Name:
Bromomethyl acetate
Risk Codes:
Design and synthesis of highly sensitive and selectivefluorescein-derived magnesium fluorescent probes and application tointracellular 3D Mg2+ imaging Some chemicals with cas registry numbers like 825628-77-1 and 590-97-6 are also used.Design and synthesis of highly sensitive and selectivefluorescein-derived magnesium fluorescent probes and application tointracellular 3D Mg2+ imaging.Komatsu, Hirokazu; Iwasawa, Naoko; Citterio, Daniel; Suzuki, Yoshio;Kubota, Takeshi; Tokuno, Kentaro; Kitamura, Yoshiichiro; Oka, Kotaro;Suzuki, Koji (Departments of Applied Chemistry and of Biosciencesand Informatics, Faculty of Science and Technology, Keio University,Yokohama, Kanagawa 223-8522, Japan). Journal of the AmericanChemical Society, 126(50), 16353-16360 (English) 2004 AmericanChemical Society. CODEN: JACSAT. ISSN: 0002-7863. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods)The role of intracellular magnesium ions is of high interest in the fieldsof pharmacol. and cellular biol. To accomplish the dynamic andthree-dimensional imaging of intracellular Mg2+, there is a strong desirefor the development of optimized Mg2+ fluorescent probes. In thispaper we describe the design, synthesis, and cellular application of thethree novel Mg2+ fluorescent probes KMG-101, -103, and -104. Thecompds. of this series feature a charged b-diketone as a binding sitespecific for Mg2+ and a fluorescein residue as the fluorophore that canbe excited with an Ar+ laser such as is widely used in confocal scanningmicroscopy. This mol. design leads to an intensive off-on-typefluorescent response toward Mg2+ ions. The two fluorescent probesKMG-103 and -104 showed suitable dissocn. consts. (Kd,Mg2+ = 2 mM)and nearly a 10-fold fluorescence enhancement over the intracellularmagnesium ion concn. range (0.1-6 mM), allowing high-contrast,sensitive, and selective Mg2+ measurements. For intracellularapplications, the membrane-permeable probe KMG-104AM wassynthesized and successfully incorporated into PC12 cells. Uponapplication of the mitochondria uncoupler FCCP to theprobe-incorporated cells, the resulting increase in the free magnesiumion concn. could be followed over time. By using a confocalmicroscope, the intracellular 3D magnesium ion concn. distributionswere satisfactorily obsd.. Preparation of carbocyclic nucleotide acyloxyalkyl esters asmembrane-permeant second messengers Preparation of carbocyclic nucleotide acyloxyalkyl esters asmembrane-permeant second messengers.Tsien, Roger Y.; Schultz, Carsten; Li, Wenhong (Regents of theUniversity of California, USA). PCT Int. Appl. WO 9640695 A1 19 Dec1996, 41 pp. DESIGNATED STATES: W: AU, CA, JP; RW: AT, BE,CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07F009-02. ICS: A61K031-025; A61K031-66. APPLICATION: WO 1996-US9923 7 Jun 1996. PRIORITY: US1995-475758 7 Jun 1995. DOCUMENT TYPE: Patent CA Section: 33(Carbohydrates) Section cross-reference(s): 6, 7Cyclitol acyloxyalkyl phosphate esters second messengers which arecapable of permeating cell membranes. Once inside the cell, the esterderivs. undergo enzymic conversion to the biol. active form of thesecond messenger. 590-97-6 and 51116-00-8 which are cas registry numbers of substances are two of reagents here. The carbocyclic nucleotide acyloxyalkyl esters,e.g., N2,O2'-dibutyryl guanosine monophosphate aacetoxymethyl esterwas prepd. as activator of intracellular protein kinase A..

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